Using different Organization based on Queue

Is there anyway, and how do I, customize the Organization based on the
Queue? Eg, if I have an email sent to support@company1.example.com vs
support@company2.example.com, they can use distinct replies for the
Organization.

Awesome product btw. RT saves my can on a daily basis.

Thanks,

Scott Edwards
– Daxal Communications - http://www.daxal.com/?from=rt